Margaret was the daughter of John Friston but her mother is unknown. The date and place of her birth have not been found.
She had two marriages/partners. Her first husband was sir Robert Rowcliffe. They were married, but the date and place have not been found. They had no known children.
Her second husband was Thomas Fairfax. They were married, but the date and place have not been found. Their only known child was Richard (?-?).