Margaret was the daughter of sir Hugh Francis but her mother is unknown. The date and place of her birth have not been found.
She had two marriages/partners. Her first husband was Thomas Garneys. They were married, but the date and place have not been found. Their only known child was John (?-?).
Her second husband was Thomas de Peyton. They were married, but the date and place have not been found. Their only known child was Francis (?-1529).