Anna was the daughter of Dirk de Wickede and Katharina van Wylich. The date and place of her birth have not been found.
Her husband was Dirk II van Bronckhorst-Anholt-Angeraen. They were married, but the date and place have not been found. Their ten known children were Diederik III (1504-1586), Elbert (15507-1529), Hendrik (1510-1536), Aleida (1512-1590), Clara (1513-1541), Otto (1516-<1517), Otto (1517-1517), Margareta (1518-1546), Jacob (1520-1520) and Katharina (1525-1605).