István was the son of János Lázár de Szentanna and Klára Apafi de Apanagyfalu. The date and place of his birth have not been found.
His wife was Borbála Bogáthy de Bogáth. They were married, but the date and place have not been found. Their four known children were Druzsianna (?-?), András (?-?), István (?-1596) and Anna (?-?).
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