María was the daughter of Rodrigo Muñoz de Guzmán and Mayor Díaz. The date and place of her birth have not been found.
Her husband was Rodrigo Gutiérrez Girón. They were married, but the date and place have not been found. Their eight known children were Gonzalo Rodríguez (c1160-1234), Gutierre Rodríguez (?-1195), Álvaro Rodríguez (?-?), Pedro Rodríguez (?-?), Nuño Rodríguez (?-?), Rodrigo Rodríguez (?-<1249), Teresa Rodríguez (?-?) and Elvira Rodríguez (?->1211).