Hippolyta was the daughter of unknown parents. The date and place of her birth have not been found.
Her husband was Gottfried IV von Hohenlohe-Weikersheim, who she married in 1478. The place has not been found. Their six known children were Johann (?-1509), Amalie (?-<1551), Thomas (?-1482), Magdalena (?-?), Anna (?-1527) and Ursula (?-1522).